Hair & Skin Biology
Hair & Skin Biology
Combining physiologically relevant human test systems with high-resolution imaging to accelerate the development of cosmetic actives, nutraceuticals, and dermatological formulations.
Immunohistochemistry & Immunofluorescence:
Substantiate anti-ageing, firming, and longevity claims through mechanistic cellular assays targeting structural breakdown and oxidative stress:
Anti-Ageing & Cellular Rejuvenation:
Substantiate anti-ageing, firming, and longevity claims through mechanistic cellular assays targeting structural breakdown and oxidative stress:
Collagen & Elastin Induction:
Quantitative measurement of Type I Collagen, Elastin, and Hyaluronic Acid (HA) synthesis in human dermal fibroblasts to evaluate structural restoration and firmness.
MMP Inhibition & Matrix Protection:
Assessment of matrix metalloproteinase inhibition (MMP-1, MMP-3, and MMP-9) to validate photo-ageing protection and extracellular matrix preservation.
Antioxidant Efficacy:
DCFH-DA probe assays in keratinocytes and fibroblasts to quantify reactive oxygen species (ROS) scavenging capacity.
Anti-Glycation Biology:
Evaluation of Advanced Glycation End-products (AGEs) inhibition to support “anti-sugar ageing” and “inner beauty” nutraceutical positioning.
Pigmentation & Skin Brightening:
Map the complete melanogenesis cascade from enzymatic synthesis to cellular transfer:
Melanogenesis Inhibition:
Direct quantification of melanin content and Tyrosinase activity in primary human melanocytes and B16F10 melanoma cell models.
Melanosome Transfer Assays:
Physiological co-culture models (melanocytes paired with keratinocytes) to assess the blockade of melanosome transfer.
Ex Vivo Skin Blanching:
Direct topical application on pigmented human skin explants to demonstrate visible brightening under real tissue architecture.
