High-Dimensional Single-Cell Analysis by Flow Cytometry
High-Dimensional Single-Cell Analysis by Flow Cytometry
In the development of targeted immunotherapies and advanced cell and gene therapies, understanding the complex dynamics of heterogeneous cell populations is critical. We utilize state-of-the-art multiparametric flow cytometry to provide high-content, quantitative cellular analysis at the single-cell level. By evaluating multiple parameters simultaneously, we deliver the deep mechanistic insights required to accelerate preclinical pipelines and validate translational biomarkers.
Our customized assay services deliver robust data across the drug discovery continuum:
Deep Immune Profiling & T-Cell Phenotyping:
Custom 10–20+ color panels validated for human PBMCs/TILs, as well as rodent (splenocytes, bone marrow, lymph nodes), NHP, and canine immune subsets.
Receptor Occupancy & Cross-Reactivity:
Quantify target engagement and confirm cross-species binding to guide human dose prediction.
Intracellular & Functional Profiling:
Single-cell cytokine staining (ICS), exhaustion markers, and proliferation across human and preclinical animal models.
Apoptosis & Viability Profiling:
To support early safety and toxicity profiling, we evaluate drug-induced apoptosis and assess overall cellular viability. This helps identify potential adverse toxic effects on various cell types prior to advancing candidates.
